Factors involved in the progression of CKD

Dr. Harriet Syme

Once loss of renal function has occurred it is thought that mal-adaptive processes (including RAS activation, glomerular hypertension, and CKD-metabolic bone disorder) contribute to intrinsic disease progression. In addition hypoxia and oxidative stress may play a role, particularly in the progressive fibrosis that occurs within the diseased kidneys. In this talk the evidence for these mechanisms will be presented and the potential clinical ramifications of this discussed.

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